french
Researchers
M-C. Brindisi, L. Brondel, F. Datiche, A. Jacquin Piques, T. Mouillot.
Enginneers and technicians
C. Forbes Fenech, S. Grall, F. Liénard, M-A. Maire.
PhD students
J. Haydar.
Post-docs
B. Abed, T. Delompré.
Trainees
H. Bouteiller.
Key words : Brain glucose sensing, hypothalamus, sweet taste detection and perception, neurons and astrocytes, ionic channels, mitochondria, metabolic pathologies (obesity, diabetes, hepatic and renal failures), food intake/behavior, metabolism.
Thematic : Control of food intake and energy metabolism
Molecular, cellular and integrated approaches to study the mechanisms that link brain nutrient sensing with the control of energy balance (food intake and metabolism), under physiological and pathological conditions in both human and animal models.
Research group in detail Open all the tabs
Theme 1 :
1) The identification of cellular and molecular actors of hypothalamic nutrient sensing and their importance in energy homeostasis
Theme 2 :
2) The understanding of how energy status under both physiological and pathological conditions alters hypothalamic nutrient detection and gustative perception. Researches are conducted by exploring the control of food intake, preferences and metabolism in human beings. Cellular and molecular hypothalamic modifications/dysregulations are examined in depth using appropriate animal models.
ANR Fat4brain 2017-2021
AFERO prize 2016: Physiological mechanisms involved in fat taste and perception in Humans.
Prize of French Society of Nutrition 2015: Brain control of food intake through gustative-evoked potentials studies in obese people: correlations with plasmatic leptin, ghrelin, insulin and dopamine levels.
BQR 2015 (financial support from the University of Burgundy): Mitochondrial redox signaling and cardio-metabolic risks associated to nutritional changes during the perinatal period.
Prize of the French Society of Diabetes 2015: Comparative study (from 3 to 9 months) of the food behavior of obese people with a type 2 diabetes treated with SGLT2 inhibitors.
ANR Connexsensing (2011-2015, financial support from the French Agency for Research): Role of astroglial connexins in hypothalamic glucose detection: implication in the nervous control of the metabolism.
IndustriaI Servier's contract (2014-15): Effect of a high fat diet-induced desynchronization on circadian rythms of insulin secretion: role of reverba and pharmacologic modulators.
Mouillot, T., Parise, A., Greco, C., Barthet, S., Brindisi, M.-C., Penicaud, L., Leloup, C., Brondel, L. and Jacquin-Piques, A. (2020). Differential cerebral gustatory responses to sucrose, aspartame, and Stevia using gustatory evoked potentials in humans. Nutrients 12(2): 322.
See the publication on PubMedBouyakdan, K., Martin, H., Liénard, F., Budry, L., Taib, B., Rodaros, D., Chrétien, C., Biron, E., Husson, Z., Cota, D., Pénicaud, L., Fulton, S., Fioramonti, X. and Alquier, T. (2019). The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system. J. Clin. Invest. 129(6): 2417-2430.
See the publication on PubMedDesmoulins, L., Chrétien, C., Paccoud, R., Collins, S., Cruciani-Guglielmacci, C., Galinier, A., Liénard, F., Quinault, A., Grall, S., Allard, C., Fenech, C., Carneiro, L., Mouillot, T., Fournel, A., Knauf, C., Magnan, C., Fioramonti, X., Pénicaud, L. and Leloup, C. (2019). Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol. Metab. 20: 166-177.
See the publication on PubMedLagrue, E. et al. (2019). A large multicenter study of pediatric myotonic dystrophy type 1 for evidence-based management. Neurology 92(8): E852-E865.
See the publication on PubMedCarneiro, L., Asrih, M., Repond, C., Sempoux, C., Stehle, J.-C., Leloup, C., Jomayvaz, F. R. and Pellerin, L. (2017). AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice. Mol. Metab. 6(12): 1625-1633.
See the publication on PubMedFioramonti, X., Chrétien, C., Leloup, C. and Pénicaud, L. (2017). Recent advances in the cellular and molecular mechanisms of hypothalamic neuronal glucose detection. Front. Physiol. 8: 875.
See the publication on PubMedKannan, M., Bayam, E., Wagner, C., Rinaldi, B., Kretz, P. F., Tilly, P., Roos, M., McGillewie, L., Bär, S., Minocha, S., Chevalier, C., Po, C., Chelly, J., Mandel, J.-L., Borgatti, R., Piton, A., Kinnear, C., Loos, B., Adams, D. J., Herault, Y., Collins, S. C., Friant, S., Godin, J. D., Yalcin, B. and Sanger_Mouse_Genetics_Project (2017). WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc. Natl. Acad. Sci. U. S. A. 114(44): E9308-E9317.
See the publication on PubMedLaperrousaz, E., Moulle, V. S., Denis, R. G., Kassis, N., Berland, C., Colsch, B., Fioramonti, X., Philippe, E., Lacombe, A., Vanacker, C., Butin, N., Bruce, K. D., Wang, H., Wang, Y., Gao, Y., Garcia-Caceres, C., Prevot, V., Tschoep, M. H., Eckel, R. H., Le Stunff, H., Luquet, S., Magnan, C. and Cruciani-Guglielmacci, C. (2017). Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice. Diabetologia 60(7): 1314-1324.
See the publication on PubMedDenimal, D., Brindisi, M.-C., Lemaire, S. and Duvillard, L. (2016). Assessment of folate status in obese patients: Should we measure folate in serum or in red blood cells? Obes. Surg. 26(12): 3069-3075.
See the publication on PubMedJacquin-Piques, A., Mouillot, T., Gigot, V., Meillon, S., Leloup, C., Pénicaud, L. and Brondel, L. (2016). Preference for sucrose solutions modulates taste cortical activity in humans. Chem. Senses 41(7): 591-599.
See the publication on PubMed
