french
Researchers
M-C. Brindisi, F. Datiche, M. Georges, T. Mouillot.
Enginneers and technicians
C. Forbes Fenech, S. Grall, F. Liénard, M-A. Maire.
PhD students
J. Haydar.
Post-docs
B. Abed, T. Delompré.
Key words : Brain glucose sensing, hypothalamus, sweet taste detection and perception, neurons and astrocytes, ionic channels, mitochondria, metabolic pathologies (obesity, diabetes, hepatic and renal failures), food intake/behavior, metabolism.
Thematic : Control of food intake and energy metabolism
Molecular, cellular and integrated approaches to study the mechanisms that link brain nutrient sensing with the control of energy balance (food intake and metabolism), under physiological and pathological conditions in both human and animal models.
Research group in detail Open all tabs
Theme 1 :
1) The identification of cellular and molecular actors of hypothalamic nutrient sensing and their importance in energy homeostasis
Theme 2 :
2) The understanding of how energy status under both physiological and pathological conditions alters hypothalamic nutrient detection and gustative perception. Researches are conducted by exploring the control of food intake, preferences and metabolism in human beings. Cellular and molecular hypothalamic modifications/dysregulations are examined in depth using appropriate animal models.
ANR Fat4brain 2017-2021
AFERO prize 2016: Physiological mechanisms involved in fat taste and perception in Humans.
Prize of French Society of Nutrition 2015: Brain control of food intake through gustative-evoked potentials studies in obese people: correlations with plasmatic leptin, ghrelin, insulin and dopamine levels.
BQR 2015 (financial support from the University of Burgundy): Mitochondrial redox signaling and cardio-metabolic risks associated to nutritional changes during the perinatal period.
Prize of the French Society of Diabetes 2015: Comparative study (from 3 to 9 months) of the food behavior of obese people with a type 2 diabetes treated with SGLT2 inhibitors.
ANR Connexsensing (2011-2015, financial support from the French Agency for Research): Role of astroglial connexins in hypothalamic glucose detection: implication in the nervous control of the metabolism.
IndustriaI Servier's contract (2014-15): Effect of a high fat diet-induced desynchronization on circadian rythms of insulin secretion: role of reverba and pharmacologic modulators.
B. Coupé, C. Leloup, K. Asiedu, J. Maillard, L. Pénicaud, T. L. Horvath and S. G. Bouret (2021). Defective Autophagy in Sf1 Neurons Perturbs the Metabolic Response to Fasting and Causes Mitochondrial Dysfunction. Molecular Metabolism, vol: 47: 101186. Impact Factor: 4.411
See the publication on PubMedT. Mouillot, A. Parise, C. Greco, S. Barthet, M.-C. Brindisi, L. Penicaud, C. Leloup, L. Brondel and A. Jacquin-Piques (2020). Differential cerebral gustatory responses to sucrose, aspartame, and Stevia using gustatory evoked potentials in humans. Nutrients, vol: 12 (2): 322. Impact Factor: 5.717
See the publication on PubMedM. Mas, M.-C. Brindisi, C. Chabanet and S. Chambaron (2020). Implicit food odour priming effects on reactivity and inhibitory control towards foods. PLoS One, vol: 15 (6): e0228830. Impact Factor: 3.240
See the publication on PubMedM. Georges, C. Rabec, E. Monin, S. Aho, G. Beltramo, J.-P. Janssens and P. Bonniaud (2020). Monitoring of noninvasive ventilation: comparative analysis of different strategies. Respiratory Research, vol: 21 (1): 324. Impact Factor: 5.631
See the publication on PubMedL. Carneiro and C. Leloup (2020). Mens sana in corpore sano: Does the glycemic index have a role to play? Nutrients, vol: 12 (10): 2989. Impact Factor: 5.717
See the publication on PubMedT. Mouillot, E. Szleper, G. Vagne, S. Barthet, D. Litime, M.-C. Brindisi, C. Leloup, L. Penicaud, S. Nicklaus, L. Brondel and A. Jacquin-Piques (2019). Cerebral gustatory activation in response to free fatty acids using gustatory evoked potentials in humans. Journal of Lipid Research, vol: 60 (3): 661-670. Impact Factor: 4.483
See the publication on PubMedL. Desmoulins, C. Chrétien, R. Paccoud, S. Collins, C. Cruciani-Guglielmacci, A. Galinier, F. Liénard, A. Quinault, S. Grall, C. Allard, C. Fenech, L. Carneiro, T. Mouillot, A. Fournel, C. Knauf, C. Magnan, X. Fioramonti, L. Pénicaud and C. Leloup (2019). Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Molecular Metabolism, vol: 20 (1): 166-177. Impact Factor: 6.448
See the publication on PubMedT. Mouillot, S. Barthet, L. Janin, C. Creteau, H. Devilliers, M.-C. Brindisi, L. Penicaud, C. Leloup, L. Brondel and A. Jacquin-Piques (2019). Taste perception and cerebral activity in the human gustatory cortex induced by glucose, fructose and sucrose solutions. Chemical Senses, vol: 44 (7): 435-447 (bjz034). Impact Factor: 2.261
See the publication on PubMedC. Chrétien, C. Fenech, F. Liénard, S. Grall, C. Chevalier, S. Chaudy, X. Brenachot, R. Berges, K. Louche, R. Stark, E. Nédélec, A. Laderrière, Z. B. Andrews, A. Benani, V. Flockerzi, J. Gascuel, J. Hartmann, C. Moro, L. Birnbaumer, C. Leloup, L. Pénicaud and X. Fioramonti (2017). Transient receptor potential canonical 3 (trpc3) channels are required for hypothalamic glucose detection and energy homeostasis. Diabetes, vol: 66 (2): 314-324. Impact Factor: 7.273
See the publication on PubMedL. Carneiro, M. Asrih, C. Repond, C. Sempoux, J.-C. Stehle, C. Leloup, F. R. Jomayvaz and L. Pellerin (2017). AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice. Molecular Metabolism, vol: 6 (12): 1625-1633. Impact Factor: 6.291
See the publication on PubMed
