french
Researchers
M-C. Brindisi, L. Brondel, A. Jacquin Piques.
Enginneers and technicians
S. Barthet, C. Forbes Fenech, S. Grall, F. Liénard.
PhD students
T. Mouillot.
Post-docs
B. Abed.
Trainees
L. Amzil, A-D. Desiree, D. Gehlot, E. Hennequin.
Key words : Brain glucose sensing, hypothalamus, sweet taste detection and perception, neurons and astrocytes, ionic channels, mitochondria, metabolic pathologies (obesity, diabetes, hepatic and renal failures), food intake/behavior, metabolism.
Thematic : Control of food intake and energy metabolism
Molecular, cellular and integrated approaches to study the mechanisms that link brain nutrient sensing with the control of energy balance (food intake and metabolism), under physiological and pathological conditions in both human and animal models.
Research group in detail Open all the tabs
Theme 1 :
1) The identification of cellular and molecular actors of hypothalamic nutrient sensing and their importance in energy homeostasis
Theme 2 :
2) The understanding of how energy status under both physiological and pathological conditions alters hypothalamic nutrient detection and gustative perception. Researches are conducted by exploring the control of food intake, preferences and metabolism in human beings. Cellular and molecular hypothalamic modifications/dysregulations are examined in depth using appropriate animal models.
ANR Fat4brain 2017-2021
AFERO prize 2016: Physiological mechanisms involved in fat taste and perception in Humans.
Prize of French Society of Nutrition 2015: Brain control of food intake through gustative-evoked potentials studies in obese people: correlations with plasmatic leptin, ghrelin, insulin and dopamine levels.
BQR 2015 (financial support from the University of Burgundy): Mitochondrial redox signaling and cardio-metabolic risks associated to nutritional changes during the perinatal period.
Prize of the French Society of Diabetes 2015: Comparative study (from 3 to 9 months) of the food behavior of obese people with a type 2 diabetes treated with SGLT2 inhibitors.
ANR Connexsensing (2011-2015, financial support from the French Agency for Research): Role of astroglial connexins in hypothalamic glucose detection: implication in the nervous control of the metabolism.
IndustriaI Servier's contract (2014-15): Effect of a high fat diet-induced desynchronization on circadian rythms of insulin secretion: role of reverba and pharmacologic modulators.
Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis. Chrétien C, Fenech C, Liénard F, Grall S, Chevalier C, Chaudy S, Brenachot X, Berges R, Louche K, Stark R, Nédélec E, Laderrière A, Andrews ZB, Benani A, Flockerzi V, Gascuel J, Hartmann J, Moro C, Birnbaumer L, Leloup C, Pénicaud L, Fioramonti X. Diabetes. 2017,66(2):314-324.
Voir la publication sur PubMedGlucose and hypothalamic astrocytes: More than a fueling role? Leloup C, Allard C, Carneiro L, Fioramonti X, Collins S, Pénicaud L. Neuroscience. 2016, 323:110-20.
Voir la publication sur PubMedPreference for Sucrose Solutions Modulates Taste Cortical Activity in Humans. Jacquin-Piques A, Mouillot T, Gigot V, Meillon S, Leloup C, Penicaud L, Brondel L. Chem Senses. 2016, 41(7):591-9.
Voir la publication sur PubMedHypothalamic sensing of ketone bodies after prolonged cerebral exposure leads to metabolic control dysregulation. Carneiro L, Geller S, Hébert A, Repond C, Fioramonti X, Leloup C, Pellerin L. Sci Rep. 2016, 6:34909.
Voir la publication sur PubMedPrandial States Modify the Reactivity of the Gustatory Cortex Using Gustatory Evoked Potentials in Humans. Jacquin-Piques A, Gaudillat S, Mouillot T, Gigot V, Meillon S, Leloup C, Penicaud L, Brondel L. Front Neurosci. 2016, 9:490.
Voir la publication sur PubMedAn integrated energy plan for activated neurons. Leloup C. J Neurochem. 2015, 135(4):639-42.
See the publication on PubMedHypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion. Allard C, Carneiro L, Grall S, Cline BH, Fioramonti X, Chrétien C, Baba-Aissa F, Giaume C, Pénicaud L, Leloup C. J Cereb Blood Flow Metab. 2014, 34(2):339-46
See the publication on PubMedHypothalamic S-nitrosylation contributes to the counter-regulatory response impairment following recurrent hypoglycemia. Fioramonti X, Deak A, Deshpande S, Carneiro L, Zhou C, Sayed N, Orban B, Berlin JR, Pénicaud L, Leloup C, Beuve A, Routh VH. PLoS One. 2013, 8(7):e68709.
See the publication on PubMedAlteration of hypothalamic glucose and lactate sensing in 48h hyperglycemic rats. Allard C, Carneiro L, Collins SC, Chrétien C, Grall S, Pénicaud L, Leloup C. Neurosci Lett. 2013, 534:75-9.
See the publication on PubMedImportance of mitochondrial dynamin-related protein 1 in hypothalamic glucose sensitivity in rats. Carneiro L, Allard C, Guissard C, Fioramonti X, Tourrel-Cuzin C, Bailbé D, Barreau C, Offer G, Nédelec E, Salin B, Rigoulet M, Belenguer P, Pénicaud L, Leloup C. Antioxid Redox Signal. 2012, 17(3):433-44.
See the publication on PubMed
