french
Researchers
D. Abed-Vieillard, G. Alves, O. Lamotte, G. Manière, M. Paoli.
Enginneers and technicians
M. Berthelot Grosjean, S. Chaudy, A. Chlémaire, C. Lemaitre-Guillier, S. Loquin.
PhD students
J. Urban, J. Vittet.
Trainees
J. Ebert.
Key words : Olfaction, SLC7A amino acid transporters, molecular genetics, cellular development, cellular physiology, food up-take, behavior, Drosophila melanogaster, brain, glia, glutamatergic neurons.
Thematic : Sensory Perception, Glia/Neuron Interactions
Odorants are key signals to detect a danger, to find a source of food, to communicate between individuals. We try to understand how these chemicals are detected and processed into the brain to lead to a specific behavioral response.
Research group in detail Open all tabs
ERC starting grant (GliSFCo, 2012-2017, YG)
ANR-JCJC (GGCB-2010, 2010-2012, YG)
Burgundy Council: PARI-FABER + postdoc fellowship (2010-2012, YG)
Masuzzo A, Manière G, Viallat-Lieutaud A, Avazeri É, Zugasti O, Grosjean Y, Kurz CL, Royet J. (2019) Peptidoglycan-dependent NF-?B activation in a small subset of brain octopaminergic neurons controls female oviposition. Elife 8. pii: e50559. doi: 10.7554/eLife.50559.
Vejux A, Abed-Vieillard D, Hajji K, Zarrouk A, Mackrill JJ, Ghosh S, Nury T, Yammine A, Zaibi M, Mihoubi W, Bouchab H, Nasser B, Grosjean Y, Lizard G. (2019) 7-Ketocholesterol and 7ß-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 3:113648. doi: 10.1016/j.bcp.2019.113648. [Epub ahead of print].
Galagovsky D, Depetris-Chauvin A, Manière G, Geillon F, Berthelot-Grosjean M, Noirot E, Alves G, Grosjean Y. (2018) Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth. Cell Rep. 24(12):3156-3166.e4. doi: 10.1016/j.celrep.2018.08.067.
Aboudhiaf S, Alves G, Parrot S, Amri M, Simonnet MM, Grosjean Y, Manière G, Seugnet L. (2018) LAT1-like transporters regulate dopaminergic transmission and sleep in Drosophila. Sleep. 41(10). doi: 10.1093/sleep/zsy137.
Ziegler AB*, Manière G*, Grosjean Y. (2018) JhI-21 plays a role in Drosophila insulin-like peptide release from larval IPCs via leucine transport. Sci Rep. 8(1):1908. doi: 10.1038/s41598-018-20394-1.
Depetris-Chauvin A, Galagovsky D, Chevalier C, Maniere G, Grosjean Y. (2017) Olfactory detection of a bacterial short-chain fatty acid acts as an orexigenic signal in Drosophila melanogaster larvae. Sci Rep. 7(1):14230. doi: 10.1038/s41598-017-14589-1.
Manière G, Grosjean Y. (2017) Drosophila and humans share similar mechanisms of insulin secretion. Med Sci (Paris). 33(2):140-141. doi: 10.1051/medsci/20173302008.
Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M. (2016) Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Hum Mol Genet. 25(24):5365-5382. doi: 10.1093/hmg/ddw352.
Manière G*, Ziegler AB*, Geillon F, Featherstone DE, Grosjean Y. (2016) Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells. Cell Rep. 17(1):137-148. doi: 10.1016/j.celrep.2016.08.093.
Ziegler AB, Augustin H, Clark NL, Berthelot-Grosjean M, Simonnet MM, Steinert JR, Geillon F, Manière G, Featherstone DE, Grosjean Y. (2016) The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in Drosophila Larvae. Sci Rep. -6:19692. doi: 10.1038/srep19692.
Ziegler A.B., Ménagé C., Grégoire S., Garcia T., Ferveur J.-F., Bretillon L. & Grosjean Y. (2015) Lack of Dietary Polyunsaturated Fatty Acids Causes Synapse Dysfunction in the Drosophila Visual System. PLOS one, 10(8), e0135353.
Depetris-Chauvin A., Galagovsky D. & Grosjean Y. (2015) Chemicals and chemoreceptors: ecologically relevant signals driving behavior in Drosophila. Frontiers in Ecology and Evolution, 3:41.
Alves G., Sallé J., Chaudy S., Dupas S. & Manière G. (2014) High-NaCl perception in Drosophila melanogaster. Journal of Neuroscience, 34, 10884-91.
Simonnet M.M., Berthelot-Grosjean M. & Grosjean Y. (2014) Testing Drosophila olfaction with a Y-maze assay. Journal of Visualized Experiments, 88.
* : co first-authorship
