chercheurs
D. Abed-Vieillard, G. Alves, O. Lamotte, G. Manière.
IngÉnieurs et techniciens
M. Berthelot Grosjean, S. Chaudy, A. Chlémaire, C. Lemaitre-Guillier, S. Loquin.
doctorants
J. Urban, J. Vittet.
Mots-clés : Olfaction, transporteurs d’acides aminés SLC7A, génétique moléculaire, développement cellulaire, physiologie cellulaire, prise alimentaire, comportement, Drosophila melanogaster, cerveau, glie, neurones glutamatergiques.
Thématique : Perception Sensorielle, Interactions Glie/Neurones
Les odeurs permettent de repérer un danger, trouver de la nourriture, communiquer entre individus. Nous cherchons à comprendre comment elles sont traitées par le cerveau pour modifier le comportement.
L'équipe en détail Ouvrir tous les onglets
ERC starting grant (GliSFCo, 2012-2017, YG)
ANR-JCJC (GGCB-2010, 2010-2012, YG)
Région Bourgogne : PARI-FABER + financement postdoc (2010-2012, YG)
Masuzzo A, Manière G, Viallat-Lieutaud A, Avazeri É, Zugasti O, Grosjean Y, Kurz CL, Royet J. (2019) Peptidoglycan-dependent NF-?B activation in a small subset of brain octopaminergic neurons controls female oviposition. Elife 8. pii: e50559. doi: 10.7554/eLife.50559.
Vejux A, Abed-Vieillard D, Hajji K, Zarrouk A, Mackrill JJ, Ghosh S, Nury T, Yammine A, Zaibi M, Mihoubi W, Bouchab H, Nasser B, Grosjean Y, Lizard G. (2019) 7-Ketocholesterol and 7ß-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 3:113648. doi: 10.1016/j.bcp.2019.113648. [Epub ahead of print].
Galagovsky D, Depetris-Chauvin A, Manière G, Geillon F, Berthelot-Grosjean M, Noirot E, Alves G, Grosjean Y. (2018) Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth. Cell Rep. 24(12):3156-3166.e4. doi: 10.1016/j.celrep.2018.08.067.
Aboudhiaf S, Alves G, Parrot S, Amri M, Simonnet MM, Grosjean Y, Manière G, Seugnet L. (2018) LAT1-like transporters regulate dopaminergic transmission and sleep in Drosophila. Sleep. 41(10). doi: 10.1093/sleep/zsy137.
Ziegler AB*, Manière G*, Grosjean Y. (2018) JhI-21 plays a role in Drosophila insulin-like peptide release from larval IPCs via leucine transport. Sci Rep. 8(1):1908. doi: 10.1038/s41598-018-20394-1.
Depetris-Chauvin A, Galagovsky D, Chevalier C, Maniere G, Grosjean Y. (2017) Olfactory detection of a bacterial short-chain fatty acid acts as an orexigenic signal in Drosophila melanogaster larvae. Sci Rep. 7(1):14230. doi: 10.1038/s41598-017-14589-1.
Manière G, Grosjean Y. (2017) Drosophila and humans share similar mechanisms of insulin secretion. Med Sci (Paris). 33(2):140-141. doi: 10.1051/medsci/20173302008.
Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M. (2016) Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Hum Mol Genet. 25(24):5365-5382. doi: 10.1093/hmg/ddw352.
Manière G*, Ziegler AB*, Geillon F, Featherstone DE, Grosjean Y. (2016) Direct Sensing of Nutrients via a LAT1-like Transporter in Drosophila Insulin-Producing Cells. Cell Rep. 17(1):137-148. doi: 10.1016/j.celrep.2016.08.093.
Ziegler AB, Augustin H, Clark NL, Berthelot-Grosjean M, Simonnet MM, Steinert JR, Geillon F, Manière G, Featherstone DE, Grosjean Y. (2016) The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in Drosophila Larvae. Sci Rep. -6:19692. doi: 10.1038/srep19692.
Ziegler A.B., Ménagé C., Grégoire S., Garcia T., Ferveur J.-F., Bretillon L. & Grosjean Y. (2015) Lack of Dietary Polyunsaturated Fatty Acids Causes Synapse Dysfunction in the Drosophila Visual System. PLOS one, 10(8), e0135353.
Depetris-Chauvin A., Galagovsky D. & Grosjean Y. (2015) Chemicals and chemoreceptors: ecologically relevant signals driving behavior in Drosophila. Frontiers in Ecology and Evolution, 3:41.
Alves G., Sallé J., Chaudy S., Dupas S. & Manière G. (2014) High-NaCl perception in Drosophila melanogaster. Journal of Neuroscience, 34, 10884-91.
Simonnet M.M., Berthelot-Grosjean M. & Grosjean Y. (2014) Testing Drosophila olfaction with a Y-maze assay. Journal of Visualized Experiments, 88.
* : co first-authorship
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